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573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem

STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, DNA-binding, & Stat3-dependent transcription.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859

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      Panoramica

      Replacement Information

      Tabella delle specifiche principali

      CAS #Empirical Formula
      501919-59-1C₁₆H₁₅NO₇S
      Description
      OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Also available as a 50 mM solution in DMSO (Cat. No. 573130).
      Catalogue Number573102
      Brand Family Calbiochem®
      Synonyms2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
      References
      ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
      Product Information
      CAS number501919-59-1
      FormLight beige solid
      Hill FormulaC₁₆H₁₅NO₇S
      Chemical formulaC₁₆H₁₅NO₇S
      HS Code2930 90 79
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      573102 0

      Documentation

      STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      573102

      Riferimenti bibliografici

      Panoramica delle referenze
      Lin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.

      Informazioni tecniche

      Titolo
      JAK/STAT Signaling Research Focus
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-March-2009 RFH
      Synonyms2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
      DescriptionA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number501919-59-1
      Chemical formulaC₁₆H₁₅NO₇S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml). Use only fresh, anhydrous DMSO.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Regulatory Review
      ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.