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420294 STAT5 Inhibitor II, IQDMA - Calbiochem

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

STAT5 Inhibitor II, IQDMA - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

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420294
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₉H₂₀N₄

Prezzi e disponibilità

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420294-10MG
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      Description
      OverviewA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
      Catalogue Number420294
      Brand Family Calbiochem®
      SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
      References
      ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.
      Product Information
      FormWhite to beige solid
      Hill FormulaC₁₉H₂₀N₄
      Chemical formulaC₁₉H₂₀N₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      420294-10MG 04055977210897

      Documentation

      STAT5 Inhibitor II, IQDMA - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      STAT5 Inhibitor II, IQDMA - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      420294

      Riferimenti bibliografici

      Panoramica delle referenze
      Su, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.

      Brochure

      Titolo
      Pathways and Biomarkers of JAK/STAT Signaling

      Informazioni tecniche

      Titolo
      JAK/STAT Signaling Research Focus
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-May-2020 JSW
      SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
      DescriptionA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
      FormWhite to beige solid
      Chemical formulaC₁₉H₂₀N₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.