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Merck

PHR1115

Stearyl Alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

1-Octadecanol, Octadecyl alcohol, Stearyl alcohol

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A propos de cet article

Formule linéaire :
CH3(CH2)17OH
Numéro CAS:
112-92-5
Poids moléculaire :
270.49
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823136
EC Number:
204-017-6
Beilstein/REAXYS Number:
1362907
MDL number:
MFCD00002823

Principaux documents

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InChI key

GLDOVTGHNKAZLK-UHFFFAOYSA-N

InChI

1S/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3

SMILES string

CCCCCCCCCCCCCCCCCCO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. S1350000, traceable to USP 1622000

vapor density

9.3 (vs air)

vapor pressure

<0.01 mmHg ( 38 °C)

API family

stearyl alcohol

CofA

current certificate can be downloaded

autoignition temp.

842 °F

expl. lim.

~8 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

300

density

0.812 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Catégories apparentées

General description

Stearyl Alcohol is added as a stiffening agent in cosmetics and pharmaceutical formulations. It is also utilized to enhance the water-holding capacity of ointments. Its other applications include the use in controlled-release tablets, suppositories, and microspheres.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Stearyl Alcohol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7161 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

nwg

flash_point_f

383.0 °F - closed cup

flash_point_c

195 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press (2009)
Stearyl Alcohol
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 40(2), 6072-6072 (2015)
Allergic contact dermatitis from stearyl alcohol in Efudix cream.
P D Yesudian et al.
Contact dermatitis, 45(5), 313-314 (2001-11-28)
Jörg Bauer et al.
Journal of the American Chemical Society, 127(20), 7296-7297 (2005-05-19)
Hydrophobically assisted switching phase (HASP) synthesis is a concept that allows the choice between the advantages of solid-supported chemistry and those of solution-phase synthesis. Starting from the examination of adsorption and desorption properties of hydrophobic molecules to and from reversed-phase
The oxorhenium(VII)-catalyzed direct condensation of phosphoric acid with an alcohol.
Akira Sakakura et al.
Angewandte Chemie (International ed. in English), 46(9), 1423-1426 (2007-01-18)
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