T5525

3,3′,5,5′-Tetramethylbenzidine

Name: 3,3′,5,5′-Tetramethylbenzidine
Brand: SIGMA

TMB substrate, chromogenic, tablet

Synonyme(s) :

BM blue, Sure Blue TMB, TMB, TMB Blotting Plus, TMB substrate

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About This Item

Formule linéaire :

[-C₆H₂(CH₃)₂-4-NH₂]₂

Numéro CAS:

54827-17-7

Poids moléculaire :

240.34

NACRES:

NA.83

PubChem Substance ID:

24900293

UNSPSC Code:

12352204

MDL number:

MFCD00007748

Beilstein/REAXYS Number:

2808541

Nom du produit

3,3′,5,5′-Tetramethylbenzidine, tablet, 1 mg substrate per tablet

InChI

1S/C16H20N2/c1-9-5-13(6-10(2)15(9)17)14-7-11(3)16(18)12(4)8-14/h5-8H,17-18H2,1-4H3

SMILES string

Cc1cc(cc(C)c1N)-c2cc(C)c(N)c(C)c2

InChI key

UAIUNKRWKOVEES-UHFFFAOYSA-N

form

tablet

mp

168-171 °C (lit.)

storage temp.

2-8°C

Quality Level

200

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Catégories apparentées

Protein Biology

Proteins & Enzymes

Detection Substrates & Enzymes

Application

3,3′,5,5′-Tetramethylbenzidine (TMB) is a noncarcinogenic substitute (Ames test negative) for benzidine suitable as peroxidase substrate for use in ELISA procedures. The substrate produces a soluble end product that is pale blue in color and can be read spectrophotometrically at 370 or 620-650 nm. The TMB reaction may be stopped with 2 M H₂SO₄ (resulting in a yellow color), and read at 450 nm. A sensitive and specific reagent for the detection of blood, assay of hemoglobin, assay of peroxidases.

3,3′,5,5′-Tetramethylbenzidine has been used as a substrate in competitive enzyme-linked immunosorbent assay (ELISA) and indirect ELISA.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351,H413

pcodes

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Carc. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Effect of acylation and enzymatic modification on pea proteins allergenicity

Szymkiewicz, A and Jedrychowski, L

Polish Journal of Food and Nutrition Sciences, 58(3) (2008)

Lactobacillus casei LcY decreases milk protein immunoreactivity of fermented buttermilk but also contains IgE-reactive proteins

Wroblewska B, et al.

Food Research International, 83, 95-101 (2016)

Immunoreactive properties of peptide fractions of cow whey milk proteins after enzymatic hydrolysis

Wroblewska B, et al.

Polish Journal of Food and Nutrition Sciences, 39(8), 839-850 (2004)

A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia.

Simon Z He et al.

Leukemia & lymphoma, 56(5), 1406-1415 (2014-09-25)

Acute myeloid leukemia (AML) blasts express high levels of interlekin-3 (IL-3) receptor-α (CD123). CSL360 is a recombinant, chimeric immunoglobulin G1 (IgG1), anti-CD123 monoclonal antibody (MoAb) that neutralizes IL-3 and demonstrates anti-leukemic activity in vitro. This phase 1 study assessed safety

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes.

Ronit Mazor et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8571-8576 (2014-05-07)

Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent anticancer agents that have produced many complete remissions in leukemia, but immunogenicity limits the number of doses that can be given

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Contenu apparenté

Product Information Sheet-T5525

Data Sheet - T5525

Instructions

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