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234115 Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem

Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Inhibitor of mitosis
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234115
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      64-86-8C₂₂H₂₅NO₆
      Description
      OverviewInhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
      Catalogue Number234115
      Brand Family Calbiochem®
      References
      ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
      Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
      Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
      Santell, L. 1992. Exp. Cell Res. 201, 358.
      Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
      Product Information
      CAS number64-86-8
      ATP CompetitiveN
      FormYellow or off-white powder
      Hill FormulaC₂₂H₂₅NO₆
      Chemical formulaC₂₂H₂₅NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibitor of mitosis
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGH0700000
      Safety Information
      R PhraseR: 26/28

      Very toxic by inhalation and if swallowed.
      S PhraseS: 13-45

      Keep away from food, drink and animal feeding stuffs.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      234115 0

      Documentation

      Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      234115

      References

      Reference overview
      Bonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
      Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
      Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
      Santell, L. 1992. Exp. Cell Res. 201, 358.
      Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-October-2009 RFH
      DescriptionMajor alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
      FormYellow or off-white powder
      CAS number64-86-8
      RTECSGH0700000
      Chemical formulaC₂₂H₂₅NO₆
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityEthanol (10 mg/ml) or H₂O
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2471
      ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
      Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
      Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
      Santell, L. 1992. Exp. Cell Res. 201, 358.
      Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.