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676492 VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

VEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I

Primary Target: VEGF receptor tyrosine kinase
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676492
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
163655-37-6C₂₁H₁₈N₂O

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676492-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
      Catalogue Number676492
      Brand Family Calbiochem®
      SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
      References
      ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
      Product Information
      CAS number163655-37-6
      ATP CompetitiveY
      DeclarationNot available for sale in Germany.
      FormRed solid
      Hill FormulaC₂₁H₁₈N₂O
      Chemical formulaC₂₁H₁₈N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationVEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.
      Biological Information
      Primary TargetVEGF receptor tyrosine kinase
      Primary Target IC<sub>50</sub>At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676492-10MG 04055977183689

      Documentation

      VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      676492

      References

      Reference overview
      Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
      DescriptionA cell-permeable, 3-substituted, indolin-2-one compound that acts as a reversible and ATP-competitive inhibitor of VEGF receptor tyrosine kinase. At low concentrations (5 µM), reported to specifically block VEGF-C and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. Reported to partially block VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential inhibition may be useful for controlling lymphangiogenesis-dependent tumor metastasis and could, therefore, be of clinical significance for cancer therapy studies.
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number163655-37-6
      Chemical formulaC₂₁H₁₈N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530