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  • Genomic instability | Life Science Research | Merck

    Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators.
  • Oxidative Stress Assays | Life Science Research | Merck

    Oxidative stress is a cellular disorder caused by an excess of free radicals resulting from increased oxidant levels, decreased anti-oxidant amounts, or failure to repair damage induced by reactive oxygen species (ROS).
  • Deregulated Nutrient Sensing | Life Science Research | Merck

    Organisms depend on multiple nutrient sensing pathways to make sure that the cells and tissue obtain just the right amount of necessary nutrients. Metabolic activities can put stress on our cells. Too much activity, and changes in nutrient availability and composition cause cells to age faster.
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