Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

530799 AGE Inhibitor, LR-90 - CAS 245075-84-7 - Calbiochem

A cell-permeable blocker of advanced glycation end product formation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Advanced Glycation Endproducts Inhibitor

Primary Target: =IF(SGM_MetricTransfer!C11=,,SGM_MetricTransfer!C11)
530799
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
245075-84-7C₃₅H₃₄Cl₂N₄O₈

Products

Catalogue NumberPackaging Qty/Pack
5.30799.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC50 = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-κB.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530799
Brand Family Calbiochem®
SynonymsAdvanced Glycation Endproducts Inhibitor
References
ReferencesSatheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
Nagai, R., et al. 2012. Diabetes. 61, 549.
Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.
Product Information
CAS number245075-84-7
FormOff-white powder
Hill FormulaC₃₅H₃₄Cl₂N₄O₈
Chemical formulaC₃₅H₃₄Cl₂N₄O₈
Quality LevelMQ100
Applications
Biological Information
Primary Target=IF(SGM_MetricTransfer!C11=,,SGM_MetricTransfer!C11)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30799.0001 04055977242980

Documentation

AGE Inhibitor, LR-90 - CAS 245075-84-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Satheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
Nagai, R., et al. 2012. Diabetes. 61, 549.
Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2014 JSW
SynonymsAdvanced Glycation Endproducts Inhibitor
DescriptionA cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC50 = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-kB.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number245075-84-7
Chemical formulaC₃₅H₃₄Cl₂N₄O₈
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSatheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
Nagai, R., et al. 2012. Diabetes. 61, 549.
Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.