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ABN433 Anti-Corticotropin-Releasing Factor Receptor 2 Antibody

This Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: CRHR2, CRF2R, CRH2R UniProt Number: Q13324
ABN433
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN433
ReplacesAB9420
DescriptionAnti-Corticotropin-Releasing Factor Receptor 2 Antibody
Alternate Names
  • Corticotropin-releasing factor receptor 2
  • CRF-R-2
  • CRF-R2
  • CRFR-2
  • Corticotropin-Releasing Factor Receptor 2
  • Corticotropin-releasing hormone receptor 2
  • CRH-R-2
  • CRH-R2
Background InformationCorticotropin-Releasing Factor Receptor 2 (CRFR2) is a G-protein coupled receptor for CRH (Corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Ligand binding activates adenylate cyclase leading to an increase in cAMP levels and subsequent gene activation. CRFR2 binds Urocortin (UCN) with the highest affinity. CRFR2 is localized to the plasma membrane, and CRFR2 has numerous isoforms but their functional importance remains to be discovered. Latest research is focused upon antagonists of the receptors for CRF. Astressin2-B, which is specific for CRFR2 and Astressin B which binds both CRFR1 and CRFR2 are two recent peptide antagonists. The research hopes to develop treatments for many CRF-dependent diseases in the periphery such as irritable bowel syndrome and even perhaps various social behaviors such as anxiety and anti-social activities.
References
Product Information
FormatAffinity Purified
HS Code3002 15 90
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in human colon and Bowman's capsule epithelial cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Corticotropin-Releasing Factor Receptor 2 near the N-terminal.
EpitopeNear N-terminal
Concentration1.0 mg/mL
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Rat, Primate, Hamster, Monkey, Mouse based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CRHR2
  • CRF2R
  • CRH2R
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~49 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing from ~45-65 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human colon tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN433 04053252981838

Documentation

Anti-Corticotropin-Releasing Factor Receptor 2 Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Corticotropin-Releasing Factor Receptor 2 Antibody Certificates of Analysis

TitleLot Number
Anti-Corticotropin-Releasing Factor Receptor 2 - Q2437454 Q2437454
Anti-Corticotropin-Releasing Factor Receptor 2 - 3207646 3207646
Anti-Corticotropin-Releasing Factor Receptor 2 - 3389899 3389899
Anti-Corticotropin-Releasing Factor Receptor 2 -2686118 2686118
Anti-Corticotropin-Releasing Factor Receptor 2 Polyclonal Antibody 3067511
Anti-Corticotropin-Releasing Factor Receptor 2 Polyclonal Antibody 3537567