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MABN531 Anti-Glypican-6 Antibody, clone 6A7.1

MABN531
100 µg  
Purchase on Sigma-Aldrich

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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, HWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN531
DescriptionAnti-Glypican-6 Antibody, clone 6A7.1
Alternate Names
  • Glypican-6
  • Secreted glypican-6
Background InformationThe protein named Glypican-6 and encoded by the gene GPC6, is a cell surface membrane proteoglycan protein that contains heparan sulfate residues and appears to act as a cellular receptor for various growth factors, ECM proteins, and enzymes. Moreover, Glypican-6 when over expressed enhances the migration and invasion of many cancer cells through the direct activation of the WNT5A signaling pathway. Additionally, Glypican-6 serves a developmental function as it is highly expressed in fetal tissues and defects give rises to severe dysmorphism and congenital defects. Glypican-6 is widely expressed in critical fetal tissues from kidney to brain, and in the adult high expression is seen in ovary, kidney, intestines and liver, and abundant in many cancer cells. Defects in Glypican-6 are associated with Omodysplasia 1 a rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia giving club-like appearance to hands and feet.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Glypican using this mouse monoclonal antibody, Anti-Glypican-6 Antibody, clone 6A7.1 validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Glypican-6 in human ovarian follicles and human oviduct tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human Glypican-6.
Clone6A7.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityShould detect both pro and secreted for Glypican-6 by immunogen design
IsotypeIgG1κ
Species Reactivity
  • Mouse
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GPC6
  • UNQ369/PRO705
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~62 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Glypican-6 in 10 µg of mouse liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN531 04053252938580