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MABT187 Anti-Kindlin-3 Antibody, clone 181A

Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.

Anti-Kindlin-3 Antibody, clone 181A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: FERMT3, KIND3, MIG2B, URP2 UniProt Number: Q86UX7
MABT187
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT187
DescriptionAnti-Kindlin-3 Antibody, clone 181A
Alternate Names
  • Fermitin family homolog 3
  • Kindlin-3
  • MIG2-like protein
  • Unc-112-related protein 2
Background InformationKindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.
References
Product Information
FormatPurified
Control
  • K562 cell lysate
PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenHis-tagged recombinant protein corresponding to human Kindlin-3.
Clone181A
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRat
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FERMT3
  • KIND3
  • MIG2B
  • URP2
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~76 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Kindlin-3 in 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABT187 04053252649622

Documentation

Anti-Kindlin-3 Antibody, clone 181A SDS

Title

Safety Data Sheet (SDS) 

Anti-Kindlin-3 Antibody, clone 181A Certificates of Analysis

TitleLot Number
Anti-Kindlin-3, clone 181A 2480966
Anti-Kindlin-3, clone 181A - 2454743 2454743
Anti-Kindlin-3, clone 181A - 2462915 2462915
Anti-Kindlin-3, clone 181A - 3225743 3225743
Anti-Kindlin-3, clone 181A - 3697336 3697336
Anti-Kindlin-3, clone 181A - Q2050288 Q2050288
Anti-Kindlin-3, clone 181A -2745867 2745867
Anti-Kindlin-3, clone 181A -2757861 2757861
Anti-Kindlin-3, clone 181A Monoclonal Antibody 2922354