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AB2971-25UG Anti-LAMP-1 (CD107a) (rabbit polyclonal)

This Anti-LAMP-1 (CD107a) Antibody is validated for use in WB, IC for the detection of LAMP-1 (CD107a).

Anti-LAMP-1 (CD107a) (rabbit polyclonal) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional, Tumor Markers Gene Symbol: LAMP1, LAMP-1, LAMPA, LGP120, CD107a UniProt Number: P11279
AB2971-25UG
25 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, R, Rhesus MacaqueWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB2971-25UG
DescriptionAnti-LAMP-1 (CD107a) (rabbit polyclonal)
Alternate Names
  • lysosomal-associated membrane protein 1
  • lysosome-associated membrane glycoprotein 1
  • Lysosome-associated membrane protein 1
  • CD107 antigen-like family member A
  • CD107a antigen
Background InformationLysosome-associated membrane protein 1 (LAMP-1) is a highly glycosolated, single-pass type 1 membrane protein belonging to the lysosome- associated membrane protein family; a group of proteins that make up the majority of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-1 functions to traffic carbohydrate ligands to selectins. It is also thought to play a role in tumor cell metastasis.
References
Product Information
FormatAffinity Purified
Control
  • EL4 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-LAMP-1 (CD107a) Antibody is validated for use in WB, IC for the detection of LAMP-1 (CD107a).
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern Blot (Snap i.d.) Analysis: 1 µg/mL from a previous lot detected LAMP-1 in 10 µg of EL4 cell lysate.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected LAMP-1 in NIH/3T3, A431, and HeLa cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human LAMP-1 at the topological domain (Lumenal).
EpitopeTopological domain (Lumenal)
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThe antibody recognizes LAMP-1 at the topological domain (Lumenal).
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Predicted to react with rhesus macaque based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq].
Gene Symbol
  • LAMP1
  • LAMP-1
  • LAMPA
  • LGP120
  • CD107a
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

PTM: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.

SEQUENCE SIMILARITIES: Belongs to the LAMP family.
Molecular Weight~ 95kDa observed. Although the calculated MW 45 kDa, LAMP-1 is heavily glycosylated and therefore, MW typically can be expected between 90-120 kDa. Uncharacterized bands may be observed in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in EL4 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-1 in 10 µg of EL4 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB2971-25UG 04054839337369

Documentation

Anti-LAMP-1 (CD107a) (rabbit polyclonal) SDS

Title

Safety Data Sheet (SDS) 

Anti-LAMP-1 (CD107a) (rabbit polyclonal) Certificates of Analysis

TitleLot Number
Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 3693164 3693164
Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 3892539 3892539
Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 4069772 4069772
Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 4137125 4137125
Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody 3126005
Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody Q2909963
Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody 3090198
Anti-LAMP-1 (CD107a) - 3352431 3352431
Anti-LAMP-1 (CD107a) - 3469480 3469480
Anti-LAMP-1 (CD107a) - 3510219 3510219