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05-878 Anti-Protein C Antibody, clone GMA-093

Anti-Protein C Antibody, clone GMA-093 detects level of Protein C & has been published & validated for use in ELISA & WB.

Anti-Protein C Antibody, clone GMA-093 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: PROC, PROC1 UniProt Number: P04070
05-878
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, WBMPurifiedMonoclonal Antibody
Description
Catalogue Number05-878
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-Protein C Antibody, clone GMA-093
References
Product Information
FormatPurified
Quality LevelMQ100
Applications
ApplicationAnti-Protein C Antibody, clone GMA-093 detects level of Protein C & has been published & validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Biological Information
ImmunogenPurified human Protein C
CloneGMA-093
HostMouse
SpecificityProtein C
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PROC
  • PROC1
Purification MethodDEAE purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P04070 # Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
SIZE: 461 amino acids; 52071 Da
SUBUNIT: Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
TISSUE SPECIFICITY: Plasma; synthesized in the liver.
PTM: The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. & Partial (70%) N-glycosylation of Asn-371 with an atypical N- X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn- 371, is beta.
DISEASE: "SwissProt: P04070 # Defects in PROC are the cause of protein C deficiency (PROC deficiency) [MIM:176860]. PROC deficiency is an important risk factor for hereditary thrombophilia [MIM:188050], a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents. A severe recessive form of PROC deficiency results in neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare and has an incidence of about 1:500,000 live births. Most cases of PROC deficiency have had a quantitative defect in the protein C molecule. PROC deficiency with a mutation that causes diminished synthesis of protein has been referred to as type I and that with synthesis of a dysfunctional molecule as type II."SIMILARITY:SwissProt: P04070 ## Belongs to the peptidase S1 family. & Contains 2 EGF-like domains. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 1 peptidase S1 domain.
MISCELLANEOUS: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin- thrombomodulin complex.
Molecular Weightnon-reduced, Mr 62kDa, reduced , Mr 41kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on human Protein C
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditionsstable 2 years at -20°C from date of shipment
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
05-878 04053252468681

Documentation

Anti-Protein C Antibody, clone GMA-093 SDS

Title

Safety Data Sheet (SDS) 

Anti-Protein C Antibody, clone GMA-093 Certificates of Analysis

TitleLot Number
Anti-Protein C, clone GMA-093 2470489
Anti-Protein C, clone GMA-093
Anti-Protein C, clone GMA-093 2479962
Anti-Protein C, clone GMA-093 - 27196 27196
Anti-Protein C, clone GMA-093 - 3266822 3266822
Anti-Protein C, clone GMA-093 - 3614086 3614086
Anti-Protein C, clone GMA-093 - 4012124 4012124
Anti-Protein C, clone GMA-093 -2564048 2564048