Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABC835 Anti-SDHD Antibody

Detect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.

Anti-SDHD Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SDHD, SD14 UniProt Number: O14521
ABC835
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC835
DescriptionAnti-SDHD Antibody
Alternate Names
  • Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
  • CybS
  • CII-4
  • QPs3
  • Succinate dehydrogenase complex subunit D
  • Succinate-ubiquinone oxidoreductase cytochrome b small subunit
  • Succinate-ubiquinone reductase membrane anchor subunit
Background InformationSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as CII-4 or QPs3 or Succinate dehydrogenase complex subunit D or Succinate-ubiquinone oxidoreductase cytochrome b small subunit or Succinate-ubiquinone reductase membrane anchor subunit, and encoded by the gene name SDHD or SD14, is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumorsuppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 2.5 μg/mL from a representative lot detected Anti-SDHD in EL4 cells.
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human Anti-SDHD.
Epitopecenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Gene Symbol
  • SDHD
  • SD14
Purification MethodAffinity
UniProt Number
Molecular Weight~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Anti-SDHD in EL4 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC835 04053252943935