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233183 Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

Primary Target: Osteoclast-mediated bone resorption
233183
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
88416-50-6CH₂Cl₂O₆P₂Na₂ • 4H₂O

Products

Catalogue NumberPackaging Qty/Pack
233183-10MGCN Plastic ampoule 10 mg
Description
OverviewA non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
Catalogue Number233183
Brand Family Calbiochem®
SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
References
ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.
Product Information
CAS number88416-50-6
ATP CompetitiveN
FormWhite solid
Hill FormulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetOsteoclast-mediated bone resorption
Primary Target IC<sub>50</sub>100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
Purity≥97% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSZ7640700
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
233183-10MGCN 04055977217773

Documentation

Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem Certificates of Analysis

TitleLot Number
233183

References

Reference overview
Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2008 RFH
SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
DescriptionA non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
FormWhite solid
CAS number88416-50-6
RTECSSZ7640700
Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
Structure formulaStructure formula
Purity≥97% by titration
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 2371
ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.