361551 Sigma-AldrichGSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem
The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 740841-15-0 | C₁₈H₁₂BrN₃O₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 361551-1MGCN | Plastic ampoule | 1 mg |
| Description | |
|---|---|
| Overview | An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems. |
| Catalogue Number | 361551 |
| Brand Family | Calbiochem® |
| Synonyms | (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime |
| References | |
|---|---|
| References | Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |
| Product Information | |
|---|---|
| CAS number | 740841-15-0 |
| ATP Competitive | N |
| Form | Dark purple solid |
| Hill Formula | C₁₈H₁₂BrN₃O₃ |
| Chemical formula | C₁₈H₁₂BrN₃O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | GSK-3α/β |
| Primary Target IC<sub>50</sub> | 10 nM against GSK-3α/β |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 361551-1MGCN | 04055977214093 |
Documentation
GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem SDS
| Title |
|---|
GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 361551 |
References
| Reference overview |
|---|
| Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |