Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

529606 InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine

529606
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
529606-1MGCN Glass bottle 1 mg
Description
OverviewA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
Catalogue Number529606
Brand Family Calbiochem®
Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
References
ReferencesIra, G., et al. 2004. Nature 431, 1011.
Papa, F.R., et al. 2003. Science 302, 1533.
Bishop, A.C., et al. 2000. Nature 407, 395.
Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
Product Information
CAS number221244-14-0
FormLiquid
FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
Hill FormulaC₂₀H₂₁N₅
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc.,
Primary Target IC<sub>50</sub>3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529606-1MGCN 04055977269956

Documentation

InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem Certificates of Analysis

TitleLot Number
529606

References

Reference overview
Ira, G., et al. 2004. Nature 431, 1011.
Papa, F.R., et al. 2003. Science 302, 1533.
Bishop, A.C., et al. 2000. Nature 407, 395.
Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-March-2013 JSW
Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
DescriptionA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
FormLiquid
FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number221244-14-0
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
Toxicity Irritant
ReferencesIra, G., et al. 2004. Nature 431, 1011.
Papa, F.R., et al. 2003. Science 302, 1533.
Bishop, A.C., et al. 2000. Nature 407, 395.
Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.