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420123 JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem

The JNK Inhibitor II, Negative Control, also referenced under CAS 54642-23-8, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N¹-Methyl-1,9-pyrazoloanthrone

Primary Target: A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
420123
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
54642-23-8C₁₅H₁₀N₂O

Products

Catalogue NumberPackaging Qty/Pack
420123-1MGCN Plastic ampoule 1 mg
Description
OverviewA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
Catalogue Number420123
Brand Family Calbiochem®
SynonymsN¹-Methyl-1,9-pyrazoloanthrone
References
ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Product Information
CAS number54642-23-8
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₅H₁₀N₂O
Chemical formulaC₁₅H₁₀N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
Primary Target IC<sub>50</sub>18 µM and 24 µM against JNK2 and JNK3, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420123-1MGCN 04055977188035

Documentation

JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem Certificates of Analysis

TitleLot Number
420123

References

Reference overview
Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.

Citations

Title
  • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-April-2011 RFH
    SynonymsN¹-Methyl-1,9-pyrazoloanthrone
    DescriptionA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
    FormYellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number54642-23-8
    Chemical formulaC₁₅H₁₀N₂O
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
    Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
    Citation
  • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    		•