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420130 JNK Inhibitor III, Cell-Permeable - Calbiochem

The JNK Inhibitor III, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂

Primary Target: JNK
420130
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉₁H₃₃₆N₇₀O₄₈S

Products

Catalogue NumberPackaging Qty/Pack
420130-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable 37-mer peptide constructed by fusing human c-Jun δ domain (amino acids 33-57) sequence with that of HIV-TAT protein transduction domain (amino acids 47-57) via a γ-aminobutyric acid (GABA) spacer. Shown to specifically disrupt c-Jun/JNK complex formation and the subsequent phosphorylation and activation of c-Jun by JNK both in vitro and in intact cells. Since its mode of inhibition is different than that of JNK Inhibitor II (SP600125; Cat. No. 420119), these two inhibitors can complement each other in JNK signaling pathway studies.
Catalogue Number420130
Brand Family Calbiochem®
SynonymsSAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
References
ReferencesHolzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.
Product Information
ATP CompetitiveN
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₉₁H₃₃₆N₇₀O₄₈S
Chemical formulaC₁₉₁H₃₃₆N₇₀O₄₈S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetJNK
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420130-1MGCN 04055977188080

Documentation

JNK Inhibitor III, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

JNK Inhibitor III, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
420130

References

Reference overview
Holzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-July-2010 JSW
SynonymsSAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
DescriptionA cell-permeable 37 amino acid peptide constructed by fusing the JNK binding domain sequence (δ) (amino acids 33-57) of human c-Jun to the HIV-TAT transduction domain sequence (amino acids 47-57) with a γ-aminobutyric acid (GABA) spacer. Reported to specifically disrupt c-Jun/JNK complex formation and subsequent phosphorylation and activation of c-Jun by JNK in vitro and in intact cells. Also reported to induce apoptosis in HeLa cells. Mode of inhibition is distinct from that of JNK Inhibitor II (SP600125; Cat. No. 420119), so may complement this inhibitor in JNK pathway studies.
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉₁H₃₃₆N₇₀O₄₈S
Peptide SequenceAc-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Acetic Acid (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesHolzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.