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12-240 MAPKAP Kinase Substrate Peptide

MAPKAP Kinase Substrate Peptide primarily used in Kinase Assays.

MAPKAP Kinase Substrate Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
12-240
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number12-240
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMAPKAP Kinase Substrate Peptide
References
Product Information
PresentationLyophilized powder
Quality LevelMQ300
Applications
ApplicationMAPKAP Kinase Substrate Peptide primarily used in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Gene Symbol
  • MAPKAPK2
  • MK2
  • MAPKAPK-2
Protein TargetMAPKAP
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P49137 # Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
SIZE: 400 amino acids; 45568 Da
SUBUNIT: Interacts with PHC2.
TISSUE SPECIFICITY: Expressed in all tissues examined.
PTM: Phosphorylated and activated by MAP kinase.
SIMILARITY: SwissProt: P49137 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for MAPKAP Kinase 2, active (14-216 & 14-337). May also be used as a substrate for MAPKAP Kinase 1.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: Stable for 2 years at 4°C
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
12-240 04053252335969

Documentation

MAPKAP Kinase Substrate Peptide SDS

Title

Safety Data Sheet (SDS) 

MAPKAP Kinase Substrate Peptide Certificates of Analysis

TitleLot Number
MAPKAP Kinase Substrate Peptide 2981173
MAPKAP Kinase Substrate Peptide 3117835
MAPKAP Kinase Substrate Peptide 2864976
MAPKAP Kinase Substrate Peptide - 2142598 2142598
MAPKAP Kinase Substrate Peptide - 2383485 2383485
MAPKAP Kinase Substrate Peptide - 16519 16519
MAPKAP Kinase Substrate Peptide - 17120 17120
MAPKAP Kinase Substrate Peptide - 17363 17363
MAPKAP Kinase Substrate Peptide - 18844 18844
MAPKAP Kinase Substrate Peptide - 2073143 2073143
Show more

References

Reference overviewApplicationPub Med ID
Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus
Suomalainen, M., et al
Embo J, 20:1310-9 (2001)  2001

Kinase Assay11250897 11250897
Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
Maroney, A. C., et al
J Neurosci, 18:104-11 (1998)  1998

Kinase Assay9412490 9412490

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Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates