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475981 Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem

The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H-RKKYKYRRK-NH₂, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV

Primary Target: Mlck
475981
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₀H₁₀₅N₂₃O₁₁

Products

Catalogue NumberPackaging Qty/Pack
475981-5MGCN Plastic ampoule 5 mg
Description
OverviewA highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
Catalogue Number475981
Brand Family Calbiochem®
SynonymsH-RKKYKYRRK-NH₂, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV
References
ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₀H₁₀₅N₂₃O₁₁
Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetMlck
Primary Target IC<sub>50</sub>50 nM against MLCK
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475981-5MGCN 04055977184365

Documentation

Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem Certificates of Analysis

TitleLot Number
475981

References

Reference overview
Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-December-2008 JSW
SynonymsH-RKKYKYRRK-NH₂, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV
DescriptionA highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.