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528245 PLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem

The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Compound 4k, PLD Inhibitor I

528245
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
939055-18-2C₂₃H₂₄FN₅O₂

Products

Catalogue NumberPackaging Qty/Pack
528245-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
Catalogue Number528245
Brand Family Calbiochem®
SynonymsCompound 4k, PLD Inhibitor I
References
ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
Product Information
CAS number939055-18-2
FormOff-white powder
Hill FormulaC₂₃H₂₄FN₅O₂
Chemical formulaC₂₃H₂₄FN₅O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528245-5MGCN 04055977196559

Documentation

PLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem Certificates of Analysis

TitleLot Number
528245

References

Reference overview
Su, W., et al. 2009. Mol Pharmacol 75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2012 JSW
SynonymsCompound 4k, PLD Inhibitor I
DescriptionA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number939055-18-2
Chemical formulaC₂₃H₂₄FN₅O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.