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676490 VEGFR2D1-7, Human, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Vascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1

676490
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
676490-50UGCN Plastic ampoule 50 μg
Description
OverviewRecombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Binding of ligand to the full-length VEGFR-2 results in a high signaling activity and mitogenic activity in endothelial cells.
Catalogue Number676490
Brand Family Calbiochem®
SynonymsVascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1
References
ReferencesRobinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.
Product Information
FormLyophilized
FormulationLyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.
Quality LevelMQ100
Applications
Biological Information
Biological activityMeasured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells
Purity≥90% by SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676490-50UGCN 04055977183665

Documentation

VEGFR2D1-7, Human, Recombinant, S. frugiperda SDS

Title

Safety Data Sheet (SDS) 

VEGFR2D1-7, Human, Recombinant, S. frugiperda Certificates of Analysis

TitleLot Number
676490

References

Reference overview
Robinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
SynonymsVascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1
DescriptionRecombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Contains all of the domains necessary for high affinity binding to VEGF. VEGFR-2 has a lower affinity for VEGF165 than VEGFR-1. However, VEGFR-2 has a higher signaling activity and is reported to mediate almost all observed endothelial cell responses to VEGF, including the increased microvascular permeability and endothelial cell proliferation. VEGFR-2 requires heparin for binding VEGF165.
FormLyophilized
FormulationLyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.
Purity≥90% by SDS-PAGE
Biological activityMeasured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells
SolubilityAqueous buffers (≥100 µg/ml) or H₂O (≥100 µg/ml)
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesRobinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.