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182200 Sigma-AldrichβARK1 Inhibitor - CAS 24269-96-3 - Calbiochem

The βARK1 Inhibitor, also referenced under CAS 24269-96-3, controls the biological activity of βARK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate

Primary Target: βARK1 (β-Adrenergic Receptor Kinase 1)

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
24269-96-3	C₁₂H₉NO₆

Products

产品目录编号	包装	数量 / 包装
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Description
Overview	A selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC₅₀ = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
Catalogue Number	182200
Brand Family	Calbiochem®
Synonyms	β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate

References
References	Iino, M., et al. 2002. J. Med. Chem. 45, 2150.

Product Information
CAS number	24269-96-3
ATP Competitive	N
Form	Yellow to orange solid
Hill Formula	C₁₂H₉NO₆
Chemical formula	C₁₂H₉NO₆
HS Code	2932 19 90
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	βARK1 (β-Adrenergic Receptor Kinase 1)
Primary Target IC<sub>50</sub>	126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
182200-5MGCN	04055977205046

Documentation

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem 分析证书

标题	批号
182200	输入批号

参考

参考信息概述
Iino, M., et al. 2002. J. Med. Chem. 45, 2150.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-August-2016 JSW
Synonyms	β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
Description	A selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC₅₀ = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.
Form	Yellow to orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	24269-96-3
Chemical formula	C₁₂H₉NO₆
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml) or Methanol
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Iino, M., et al. 2002. J. Med. Chem. 45, 2150.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > ß Adrenergic Receptor Kinase Inhibitors

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