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05-726 Anti-53BP1 Antibody, clone BP13

05-726
200 µg  
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      概述

      Replacement Information

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-726
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-53BP1 Antibody, clone BP13
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationDetect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Application NotesDoes not cross-react with mouse.
      Biological Information
      ImmunogenMix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1
      Cloneclone BP13
      HostMouse
      Specificity53BP1
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TP53BP1
      • 53BP1
      • p53BP1
      • p202
      • FLJ41424
      • MGC138366
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12888 # May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage.
      SIZE: 1972 amino acids; 213574 Da
      SUBUNIT: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H3 that has been methylated on 'Lys-79'. Does not bind unmethylated histone H3.
      SUBCELLULAR LOCATION: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.
      PTM: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. & Phosphorylated in an ATM-dependent manner in response to DNA damage.
      SIMILARITY: SwissProt: Q12888 ## Contains 2 BRCT domains.
      Molecular Weight~250kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on lysates from HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-53BP1 Antibody, clone BP13 MSDS

      职位

      物料安全数据表 (MSDS) 

      Anti-53BP1 Antibody, clone BP13 分析证书

      标题批号
      Anti-53BP1, clone BP13 (mouse monoclonal IgG1) - 2430523 2430523
      Anti-53BP1, clone BP13 (mouse monoclonal IgG1) 3002886
      Anti-53BP1, clone BP13 (mouse monoclonal IgG1) 3123643
      Anti-53BP1, clone BP13 - 24568 24568
      Anti-53BP1, clone BP13 - 3263245 3263245
      Anti-53BP1, clone BP13 - 3474178 3474178

      参考

      参考概述公共医疗ID
      Spatial dynamics of DNA damage response protein foci along the ion trajectory of high-LET particles.
      Guanghua Du,Guido A Drexler,Werner Friedland,Christoph Greubel,Volker Hable,Reiner Krücken,Alexandra Kugler,Laura Tonelli,Anna A Friedl,Günther Dollinger
      Radiation research  176  2011

      显示摘要
      21797665 21797665
      Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.
      Fay Minty, Johanna K Thurlow, Paul R Harrison, E Kenneth Parkinson
      Experimental cell research  314  2434-47  2008

      显示摘要
      18589416 18589416
      Quantitative analysis of DNA-damage response factors after sequential ion microirradiation.
      Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel, Hilmar Strickfaden, Iris Baur, Reiner Krücken, Thomas Cremer, Anna A Friedl, Günther Dollinger, Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel, Hilmar Strickfaden, Iris Baur, Reiner Krücken, Thomas Cremer, Anna A Friedl, Günther Dollinger, Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel, Hilmar Strickfaden, Iris Baur, Reiner Krücken, Thomas Cremer, Anna A Friedl, Günther Dollinger
      Radiation and environmental biophysics  47  415-22  2008

      显示摘要
      18648840 18648840
      Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.
      Rappold, I, et al.
      J. Cell Biol., 153: 613-20 (2001)  2001

      显示摘要
      11331310 11331310
      Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
      Ward, I M and Chen, J
      J. Biol. Chem., 276: 47759-62 (2001)  2001

      显示摘要
      11673449 11673449

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      种类

      Life Science Research > Antibodies and Assays > Primary Antibodies