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ABN240 Anti-Amyloid, β 1-40, aβ Antibody

Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.

Anti-Amyloid, β 1-40, aβ Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: APP, A4, AD1 UniProt Number: P05067
ABN240
100 µL  
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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P), ELISARbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN240
ReplacesAB5737
DescriptionAnti-Amyloid, β 1-40, aβ Antibody
Alternate Names
  • Amyloid beta A4 protein
  • ABPP
  • APPI
  • APP
  • Alzheimer disease amyloid protein
  • Cerebral vascular amyloid peptide
  • CVAP
  • PreA4
  • Protease nexin-II
  • PN-II
  • 1.N-APP2.Soluble APP-alpha
  • S-APP-alpha3.Soluble APP-beta
  • S-APP-beta4.C995.Beta-amyloid protein 42
  • Beta-APP426.Beta-amyloid protein 40
  • Beta-APP407.C838.P3(42)9.P3(40)10.C8011.Gamma-secretase C-terminal fragment 59
  • Amyloid intracellular domain 59
  • AICD-59
  • AID(59)
  • Gamma-CTF(59)12.Gamma-secretase C-terminal fragment 57
  • Amyloid intracellular domain 57
  • AICD-57
  • AID(57)
  • Gamma-CTF(57)13.Gamma-secretase C-terminal fragment 50
  • Amyloid intracellular domain 50
  • AICD-50
  • AID(50)
  • Gamma-CTF(50)14.C31
Background InformationAmyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.
References
Product Information
FormatAffinity Purified
Control
  • Human Alzhiemer brain tissue lysate
PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
  • ELISA
Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer's diseased brain tissue.

ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.
EpitopeP3(40) peptide
HostRabbit
SpecificityThis antibody recognizes the P3(40) peptide of Amyloid, β 1-40.
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • APP
  • A4
  • AD1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human Alzheimer brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABN240 04053252648830

Documentation

Anti-Amyloid, β 1-40, aβ Antibody MSDS

职位

物料安全数据表 (MSDS) 

Anti-Amyloid, β 1-40, aβ Antibody 分析证书

标题批号
Anti-Amyloid, 1-40, a - 2262714 2262714
Anti-Amyloid, #946; 1-40, a#946; - Q2027064 Q2027064
Anti-Amyloid, β 1-40, aβ 2480958
Anti-Amyloid, β 1-40, aβ - 3258754 3258754
Anti-Amyloid, β 1-40, aβ - 3403479 3403479
Anti-Amyloid, β 1-40, aβ - 3984068 3984068
Anti-Amyloid, β 1-40, aβ - 4018523 4018523
Anti-Amyloid, β 1-40, aβ - 4277688 4277688
Anti-Amyloid, β 1-40, aβ -2652009 2652009
Anti-Amyloid, β 1-40, aβ -2657491 2657491
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Newsletters / Publications

Title
Research Focus - Volume 2, 2013