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ABN1008 Anti-ENTPD1 Antibody

This Anti-ENTPD1 Antibody is validated for use in Western Blotting, Flow Cytometry for the detection of ENTPD1.

Anti-ENTPD1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: ENTPD1, CD39 UniProt Number: P49961
ABN1008
100 μg  
Purchase on Sigma-Aldrich

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概述

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, FCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1008
DescriptionAnti-ENTPD1 Antibody
Alternate Names
  • Ectonucleoside triphosphate diphosphohydrolase 1
  • NTPDase 1
  • Ecto-ATP diphosphohydrolase 1
  • Ecto-ATPDase 1
  • Ecto-ATPase 1
  • Ecto-apyrase
  • Lymphoid cell activation antigen
  • CD39
  • ENTPD1
  • NTPDase1
Background InformationEctonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5; UniProt P49961; also known as CD39, Ecto-apyrase, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Lymphoid cell activation antigen, NTPDase 1) is encoded by the ENTPD1 (also known as CD39, SPG64) gene (Gene ID 953) in human. CD39 is a cell surface nucleotide-metabolizing enzyme that hydrolyzes extracellular purine NTP and NDP. CD39 is a putative marker for B-cell activation and its expression is also observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis. E. coli infection is reported to induce CD39 promoter activity in macrophages, resulting in an upregulated CD39 expression during sepsis in mice, while CD39 knockdown increases mortality among mice with polymicrobial sepsis.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-ENTPD1 Antibody is validated for use in Western Blotting, Flow Cytometry for the detection of ENTPD1.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected ENTPD1 in 10 µg of human spleen and Jurkat cell lystaes.
Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected ENTPD1 in 1X10E6 Jurkat cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human ENTPD1.
Epitopeextracellular domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityExpeccted to react with all six spliced isoforms, including the Vascular and the Placenta I&II isoforms.
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Primate based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • ENTPD1
  • CD39
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~65 kDa observed when using human placenta tissue lysates. Glycosylated target band(s) will appear larger than the calculated molecular weights of 58.0 kDa (Isoform 1/Vascular), 58.7 kDa ((Isoform 2/Placenta I), 34.2 kDa (Isoform 3/Placenta II), 42.7 kDa (Isoform 4), 46.2 kDa (Isoform 5), and 59.3 kDa (Isoform 6). Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human placenta cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected ENTPD1 in 10 µg of human placenta cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABN1008 04055977277340