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MABS808 Anti-GSK3 alpha, clone 9D5G1 Antibody

Anti-GSK3 alpha, clone 9D5G1 Antibody is an antibody against GSK3 alpha for use in Western Blotting, Immunocytochemistry.

Anti-GSK3 alpha, clone 9D5G1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: GSK3B UniProt Number: P49840
MABS808
100 µL  
Purchase on Sigma-Aldrich

特卖

概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMAscitesMonoclonal Antibody
Description
Catalogue NumberMABS808
Replaces04-360
DescriptionAnti-GSK3 alpha, clone 9D5G1 Antibody
Alternate Names
  • Glycogen synthase kinase-3 betaGSK-3 beta
  • GSK3 alpha
Background InformationGlycogen synthase kinase 3 alpha (GSK3A) belongs to the Ser/Thr family of protein kinases. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
References
Product Information
FormatAscites
PresentationMouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-GSK3 alpha, clone 9D5G1 Antibody is an antibody against GSK3 alpha for use in Western Blotting, Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis (ICC): A 1:200-1,000 dilution from a representative lot detected GSK3 alpha in HeLa cells.
Biological Information
ImmunogenPurified recombinant fragment of GSK3 alpha expressed in E. Coli.
Clone9D5G1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • GSK3B
Purification MethodUnpurified
UniProt Number
Molecular Weight~ kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa and PC-3 cell lysates.

Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected GSK3 alpha in HeLa and PC-3 cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABS808 04055977172195