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ABC248 Anti-HPGD Antibody

Detect Prostaglandin dehydrogenase 1 using this rabbit polyclonal antibody, Anti-HPGD Antibody validated for use in western blotting & IHC.

Anti-HPGD Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: HPGD, PGDH1 UniProt Number: P15428
ABC248
100 µg  
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Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC248
DescriptionAnti-HPGD Antibody
Alternate Names
  • 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • Prostaglandin dehydrogenase 1
  • 15-PGDH
Background InformationThe protein named HPGD, or also known as 15-PGDH, or Prostaglandin dehydrogenase 1, and encoded by the gene HPGD/PGDH1, is a protein necessary for the regulation of prostaglandin levels. Prostaglandins are potent inflammatory agents, thus their regulation is key for control inflammatory responses. HPGD works to mediate prostaglandin inactivation by catalyzing the NAD dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoin A4. Additionally, HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is localized to the cytoplasm. HPGD is expressed in intestinal and colon tissues. HPGD is down regulated in colon cancer and thus is being examined as a therapeutic agent. Defects in HPGD may be associated with Hypertrophic osteoarthropathy, a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Other diseases associated with this gene’s defects are Crainoosteoarthropathy (swollen joint disease) and congenital nail clubbing where one has very large nails on the fingers and toes.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Prostaglandin dehydrogenase 1 using this rabbit polyclonal antibody, Anti-HPGD Antibody validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected HPGD in human ileum tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human HPGD.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Primate, Chimpanzee, Monkey, Baboon, and Rabbit based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • HPGD
  • PGDH1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~32 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Caco-2 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected HPGD in 10 µg of Caco-2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABC248 04053252937408