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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

06-429-I Sigma-AldrichAnti-IGF-IRα subunit Antibody

This Anti-IGF-IRα subunit Antibody is validated for use in Western Blotting, Immunoprecipitation, Immunocytochemistry for the detection of IGF-IRα subunit.

Anti-IGF-IRα subunit Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
小册子
技术信息
Posters

Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: IGF1R UniProt Number: P08069

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IP, ICC	Ch	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	06-429-I
Description	Anti-IGF-IRα subunit Antibody
Alternate Names	Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor CD221 Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain IGF-IRα subunit
Background Information	Insulin-like growth factor 1 receptor (EC:2.7.10.1; UniProt P08069; also known as CD221, IGF-I receptor, Insulin-like growth factor I receptor) is encoded by the IGF1R (also known as CD221, IGFIR, IGFR, JTK13) gene (Gene ID 3480) in human. The insulin-like growth factor 1 (IGF-1) receptor has tyrosine kinase that is activated by IGF-1 and IGF-2 binding. IGF-1 receptor is initially produced as a precursor protein with an aignal peptide sequence (aa 1-30). Post-translational cleavages produce one extracellular alpha (aa 31-736) chain and one transmembrane beta chain (aa 741 – 1367) linked together by a disulfide bond. Two sets of alpha-beta dimers then form the functional tetrameric receptor complex via a disulfide linkage between their alpha chain. Upon ligand binding, the alpha chains induce the tyrosine auto-phosphorylation of the beta chains, which in turn triggers cell type-specific downstream signaling cascade of events.

References

Product Information
Format	Affinity Purified
Presentation	Purified chicken polyclonal IgY antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-IGF-IRα subunit Antibody is validated for use in Western Blotting, Immunoprecipitation, Immunocytochemistry for the detection of IGF-IRα subunit.
Key Applications	Western Blotting Immunoprecipitation Immunocytochemistry
Application Notes	Immunoprecipitation Analysis: 5.0 µg from a representative lot immunoprecipitated human IGF-IRα subunit in 0.5 mg of human IGF-IR-expressing C4 cell lysate. Immunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected IGF-IRα subunit in human IGF-IR-expressing C4 cells.

Biological Information
Immunogen	KLH-conjugated synthetic peptide [C-KYADGTIDIEEVTENPKT] corresponding to amino acid residues 672-689 of human IGF-IR alpha chain.
Epitope	Third Fibronectin Type III (FnIII 3) domain
Concentration	Please refer to lot specific datasheet.
Host	Chicken
Isotype	IgY
Species Reactivity	Human
Species Reactivity Note	Human. Predicted to react with Rhesus Macaque based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_000866
Gene Symbol	IGF1R
Purification Method	Affinity Purfied
UniProt Number	P08069
Molecular Weight	~110/180 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human IGF-IR-expressing murine fibroblast LISN C4 cell lysate. Western Blotting Analysis: 0.2 µg/mL of this antibody detected IGF-IRα subunit in 10 µg of human IGF-IR-expressing murine fibroblast LISN C4 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
06-429-I	04055977182453

Documentation

Anti-IGF-IRα subunit Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-IGF-IRα subunit Antibody 分析证书

标题	批号
Anti-IGF-IRα subunit - 3268883	3268883
Anti-IGF-IRα subunit - 4045750	4045750
Anti-IGF-IRα subunit -Q2589621	Q2589621
Anti-IGF-IRα subunit -Q2589625	Q2589625

小册子

标题
New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody

技术信息

标题
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

海报

标题
Post-Translational Modifications

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05-1571	Anti-IGF-1R Antibody, clone 24-57
05-656	Anti-IGF-IR Antibody, clone JBW902
06-429	Anti-IGF-IRα subunit Antibody
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MABS1301	Anti-IGF-IRα subunit Antibody, clone 1B1

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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