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ABN253 Anti-PTGDS Antibody

Detect the PTGDS protein using this Anti-PTGDS validated for use in WB & IHC.

Anti-PTGDS Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: PTGDS, PDS UniProt Number: P41222
ABN253
100 µg  
Purchase on Sigma-Aldrich

特卖

概述

Replacement Information

特卖

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, Rhesus MacaqueWB, IHCRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABN253
DescriptionAnti-PTGDS Antibody
Alternate Names
  • Prostaglandin-H2 D-isomerase
  • Beta-trace protein
  • Cerebrin-28
  • Glutathione-independent PGD synthase
  • Lipocalin-type prostaglandin-D synthase
  • Prostaglandin-D2 synthase
  • PGD2 synthase
  • PGDS
  • PGDS2
Background InformationProstaglandin-H2 D-isomerase (PTGDS), also known the Lipocalin-type prostaglandin-D synthase, catalyzes the conversion of PGH2 to PGD2. PTGDS serves both as a PGD2-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. It is the only enzyme in the lipocalin type protein family, members of which mainly act as binding proteins. It has been shown to bind various small, lipophilic compounds such as retinoic acid, biliverdin, bilirubin, retinoic acid, and thyroid hormone and may act as a scavenger for harmful hydrophobic molecules. In cells it is localized in the endoplasm reticulum, golgi apparatus, cell membrane, and is also secreted. PTGDS is involved in several central nervous system functions, such as sedation, pain regulation and non-rapid eye movement sleep. It is suggested to be involved in development and maintenance of the blood-brain, blood-retina, and blood-aqueous humor barriers and may also play a role in maturation and maintenance of the central nervous system.
References
Product Information
FormatPurified
Control
  • Human testis tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect the PTGDS protein using this Anti-PTGDS validated for use in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: 1:100 dilution from a representative lot detected PTGDS in human pons/midbrain and human cardiac myocytes.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PTGDS.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Rhesus Macaque
Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Feline (92% sequence homology), Canine (83% sequence homology), Mouse (75% sequence homology), no homology to Rat detected.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PTGDS
  • PDS
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~30 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human testis tissue lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected PTGDS in 10 µg of human testis tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABN253 04053252830563