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ABN111 Anti-RGS11 (CT) Antibody

Detect RGS11 (C-terminus) using this Anti-RGS11 (C-terminus) Antibody validated for use in Western Blotting.

Anti-RGS11 (CT) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: RGS11 UniProt Number: O94810
ABN111
100 µg  
Purchase on Sigma-Aldrich

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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABN111
DescriptionAnti-RGS11 (CT) Antibody
Alternate Names
  • Regulator of G-protein signaling 11
  • RGS11
Background InformationRegulator of G-protein signaling 11 (RGS11) is a multidomain GTPase containing one each of DEP, RGS, and G-protein gamma domains. Like other members of the R7 RGS family, RGS11 uses these domains to form multisubunit complexes, which process the light responses of retinal cells. RGS11 interacts with the RGS9 anchor protein (R9AP) and the 5 G-protein beta subunit (Gbeta5) to form a trimeric complex that regulates the activity of the metabotropic glutamate receptor 6 (mGluR6) in ON-bipolar cells. The RGS11 complex hydrolyzes GTP and inactivates the G-protein Galphao, which is activated by mGluR6 in dark environments. By this mechanism, the RGS11 complex accelerates the light response in ON-bipolar retinal cells.
References
Product Information
FormatPurified
Control
  • Human placenta tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationDetect RGS11 (C-terminus) using this Anti-RGS11 (C-terminus) Antibody validated for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human RGS11.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the C-terminus of RGS11.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • RGS11
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~53 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected RGS11 in 10 µg of human placenta tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABN111 04053252440809