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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABF290 Sigma-AldrichAnti-S100A9 Antibody, clone 2A5 (Azide Free)

Anti-S100A9 Antibody, clone 2A5 (Azide Free) is an antibody against S100A9 for use in western blotting & activity assay.

Anti-S100A9 Antibody, clone 2A5 (Azide Free) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: S100a9, Cagb, Mrp14 UniProt Number: P31725

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, ACT	R	Purified	Monoclonal Antibody

Description
Catalogue Number	MABF290
Description	Anti-S100A9 Antibody, clone 2A5 (Azide Free)
Alternate Names	Protein S100-A9 Calgranulin-B Leukocyte L1 complex heavy chain Migration inhibitory factor-related protein 14 MRP-14 p14 S100 calcium-binding protein A9
Background Information	S100A9, also known as Calgranulin-B, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, or S100 calcium-binding protein A9, and encoded by the gene S100A9/CAGB/MRP14/S100-A9 is a calcium and zinc binding protein that plays a prominent role in the regulation of inflammatory processes and immune responses. S100-A9 can induce neutrophil chemotaxis and adhesion. S100-A9 one of the subunits of Calprotectin, which is a complex of S100-A8 and S100-A9 proteins and is also critical for immune responses. S100-A9 is a cytoplasmic and secreted protein predominantly expressed in myeloid cells as well as neutrophils and monocytes but not expressed in lymphocytes. S100-A9 is found in high concentrations at sites of inflammation or in the serum of patients with inflammatory diseases. S100-A9 is also a cancer marker as it is up regulated in many cancers including gastric, esophageal, colon, breast and many more.

References

Product Information
Format	Purified
Presentation	Purified rat monoclonal IgG1 in buffer containing PBS without preservatives.
Quality Level	MQ100

Applications
Application	Anti-S100A9 Antibody, clone 2A5 (Azide Free) is an antibody against S100A9 for use in western blotting & activity assay.
Key Applications	Western Blotting Activity Assay
Application Notes	Activity Assay Analysis: A representative lot detected S100A9 and found that it increases neutrophil migration & induces the secretion of cytokines by monocytes (Cesaro, A., et al. (2012). PLOS ONE. 7(9):e45478 1-12). Western Blotting Analysis: A representative lot detected S100A9 in mouse neutrophils and recombinant mS100A9 (Cesaro, A., et al. (2012). PLOS ONE. 7(9):e45478 1-12).

Biological Information
Immunogen	Recombinant protein corresponding to mouse S100A9.
Clone	2A5
Concentration	1 mg/mL
Host	Rat
Isotype	IgG1
Species Reactivity	Human Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_00126878
Gene Symbol	S100a9 Cagb Mrp14
Purification Method	Protein G Purified
UniProt Number	P31725
Molecular Weight	~15 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in Raji cell lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected S100A9 in 10 µg of Raji cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABF290	04053252975677

Documentation

Anti-S100A9 Antibody, clone 2A5 (Azide Free) MSDS

职位
物料安全数据表 (MSDS)

Anti-S100A9 Antibody, clone 2A5 (Azide Free) 分析证书

标题	批号
Anti-S100A9, clone 2A5 (Azide Free) - Q2426886	Q2426886
Anti-S100A9, clone 2A5 (Azide Free) - 3384392	3384392
Anti-S100A9, clone 2A5 (Azide Free) - 3598001	3598001
Anti-S100A9, clone 2A5 (Azide Free) - 3707325	3707325
Anti-S100A9, clone 2A5 (Azide Free) - 3949757	3949757
Anti-S100A9, clone 2A5 (Azide Free) Monoclonal Antibody	3126686

参考

参考概述	公共医疗ID
An inflammation loop orchestrated by S100A9 and calprotectin is critical for development of arthritis. Cesaro, Annabelle, et al. PLoS ONE, 7: e45478 (2012) 2012 显示摘要 The S100A9 and S100A8 proteins are highly expressed by neutrophils and monocytes and are part of a group of damage-associated molecular pattern molecules that trigger inflammatory responses. Sera and synovial fluids of patients with rheumatoid arthritis (RA) contain high concentrations of S100A8/A9 that correlate with disease activity.	23029038

参考概述

公共医疗ID

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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