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ABN418 Anti-TRPM4 Antibody

Anti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.

Anti-TRPM4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: TRPM4, LTRPC4 UniProt Number: Q8TD43
ABN418
100 µg  
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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN418
DescriptionAnti-TRPM4 Antibody
Alternate Names
  • Transient receptor potential cation channel subfamily M member 4
  • hTRPM4
  • Calcium-activated non-selective cation
  • channel 1
  • Long transient receptor potential channel 4
  • LTrpC-4
  • LTrpC4
  • Melastatin-4
Background InformationTRPM4, also known as Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-4 or LTrpC4, and encoded by the gene TRPM4/LTRPC4, is a calcium activated non-selective ion channel for Na+, K+, Cs+ and Li+ ions. TRPM4 plays a central role in membrane depolarization in cardiomyocytes, cortical and dorsal root neurons, endocrine cells, kidney epithelial cells and even hair cells. Additionally, TRPM4 participates in T-cell activation, IL-2 production, blood vessel constriction, insulin secretion and even cell proliferation in various cell types through the up regulation of the beta catenin signaling pathway. TRPM4 is localized to the cell membrane and golgi apparatus and endoplasmic reticulum. TRPM4 is widely expressed. Defects in TRPM4 may be associated with progressive familial heart block disorder which can be a fatal though unpredictable syndrome.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRPM4 in human cerebellum and human prostate tissue.
Biological Information
ImmunogenBCP-conjugated linear peptide corresponding to human TRPM4 near the N-terminal.
EpitopeNear N-terminal
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Chimpanzee, Monkey, Mouse based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TRPM4
  • LTRPC4
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~150 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~130 kDa and ~147 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human cerebellum tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRPM4 in 10 µg of human cerebellum tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABN418 04053252958199