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538763 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor

Primary Target: CD38
538763
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1700637-55-3C₂₂H₂₇N₃O₃S

Products

产品目录编号包装 数量 / 包装
5.38763.0001 玻璃瓶 10 mg
Description
OverviewA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
Catalogue Number538763
Brand Family Calbiochem®
SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
References
ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
Product Information
CAS number1700637-55-3
FormWhite to light brown to brown solid
Hill FormulaC₂₂H₂₇N₃O₃S
Chemical formulaC₂₂H₂₇N₃O₃S
HS Code2934 10 90
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetCD38
Primary Target IC<sub>50</sub>7.3 & 1.9 nM for human & mouse CD38, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
5.38763.0001 04054839119507

Documentation

CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem 分析证书

标题批号
538763

参考

参考信息概述
Haffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-July-2019 JSW
SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
DescriptionA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
FormWhite to light brown to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1700637-55-3
Chemical formulaC₂₂H₂₇N₃O₃S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.