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238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol

Primary Target: Cdk9
238811
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
140651-18-9C₉H₁₀N₆O

Products

产品目录编号包装 数量 / 包装
238811-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
Catalogue Number238811
Brand Family Calbiochem®
Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
References
ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.
Product Information
CAS number140651-18-9
ATP CompetitiveY
FormOrange solid
Hill FormulaC₉H₁₀N₆O
Chemical formulaC₉H₁₀N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk9
Primary Target IC<sub>50</sub>350 nM, using Cdk9/T1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
238811-5MGCN 04055977216646

Documentation

Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem 分析证书

标题批号
238811

参考

参考信息概述
Krystof, V., et al. 2006. J. Med. Chem. 49, 6500.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2007 JSW
Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
DescriptionA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number140651-18-9
Chemical formulaC₉H₁₀N₆O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.