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343290 Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

Primary Target: Selective serotonin re-uptake inhibitor
343290
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
56296-78-7C₁₇H₁₈F₃NO • HCL

Products

产品目录编号包装 数量 / 包装
343290-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
Description
OverviewA cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.
Catalogue Number343290
Brand Family Calbiochem®
Synonymsdl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
References
ReferencesBartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.
Product Information
CAS number56296-78-7
ATP CompetitiveN
FormSolid
Hill FormulaC₁₇H₁₈F₃NO • HCL
Chemical formulaC₁₇H₁₈F₃NO • HCL
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSelective serotonin re-uptake inhibitor
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
343290-25MGCN 04055977195101

Documentation

Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem 分析证书

标题批号
343290

参考

参考信息概述
Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-July-2017 JSW
Synonymsdl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
DescriptionA cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca2+ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K+ currents in a reversible and voltage-independent manner (IC50 = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number56296-78-7
Chemical formulaC₁₇H₁₈F₃NO • HCL
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml) or Methanol (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 4185
ReferencesBartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.