529606 Sigma-AldrichInSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
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概述
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Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 529606-1MGCN | 玻璃瓶 | 1 mg |
| Description | |
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| Overview | A cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. |
| Catalogue Number | 529606 |
| Brand Family | Calbiochem® |
| Synonyms | 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine |
| Product Information | |
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| CAS number | 221244-14-0 |
| Form | Liquid |
| Formulation | A 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO. |
| Hill Formula | C₂₀H₂₁N₅ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | mutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc., |
| Primary Target IC<sub>50</sub> | 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 529606-1MGCN | 04055977269956 |
Documentation
InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem MSDS
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InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem 分析证书
| 标题 | 批号 |
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| 529606 |
参考
| 参考信息概述 |
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| Ira, G., et al. 2004. Nature 431, 1011. Papa, F.R., et al. 2003. Science 302, 1533. Bishop, A.C., et al. 2000. Nature 407, 395. Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677. Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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