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407272 Integrin αvβ3 Antagonist, P11 - Calbiochem

The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.

Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: HSDVHK-NH2, HSDVHK

407272
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概述

Replacement Information

重要规格表

Empirical Formula
C₃₀H₅₁N₁₂O₉₃· 3TFA

Products

产品目录编号包装 数量 / 包装
407272-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
Catalogue Number407272
Brand Family Calbiochem®
SynonymsHSDVHK-NH2, HSDVHK
References
ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
Product Information
FormWhite solid
FormulationSupplied as a trifluoracetate salt.
Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
407272-5MGCN 04055977188769

Documentation

Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Integrin αvβ3 Antagonist, P11 - Calbiochem 分析证书

标题批号
407272

参考

参考信息概述
Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-jul-2012
SynonymsHSDVHK-NH2, HSDVHK
DescriptionA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
FormWhite solid
FormulationSupplied as a trifluoracetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.