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410960 Ischemin - CAS 1357059-00-7 - Calbiochem

A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.

Ischemin - CAS 1357059-00-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II

410960
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1357059-00-7C₁₅H₁₇N₃SO₄

Products

产品目录编号包装 数量 / 包装
410960-25MGCN 玻璃瓶 25 mg
Description
OverviewA cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (Kd = 19 µM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B (Kd = 37, 41, 70 and > 100 µM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC50 = 5 µM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions.
Catalogue Number410960
Brand Family Calbiochem®
Synonyms(E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II
References
ReferencesBorah, J.C., et al. 2011, Chem. Biol. 18, 531.
Product Information
CAS number1357059-00-7
FormOrange-red solid
Hill FormulaC₁₅H₁₇N₃SO₄
Chemical formulaC₁₅H₁₇N₃SO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
410960-25MGCN 04055977211153

Documentation

Ischemin - CAS 1357059-00-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Ischemin - CAS 1357059-00-7 - Calbiochem 分析证书

标题批号
410960

参考

参考信息概述
Borah, J.C., et al. 2011, Chem. Biol. 18, 531.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms(E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II
DescriptionA cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (Kd = 19 µM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B (Kd = 37, 41, 70 and > 100 µM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC50 = 5 µM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions.
FormOrange-red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1357059-00-7
Chemical formulaC₁₅H₁₇N₃SO₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml; orange solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesBorah, J.C., et al. 2011, Chem. Biol. 18, 531.