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530153 JAK2 Inhibitor X, FLLL32 - 1260115-54-5 - Calbiochem

A cell permeable analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 and PANC-1 cancer cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: STAT3 Signaling Inhibitor, FLLL32

Primary Target: JAK2
530153
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1260115-54-5C₂₈H₃₂O₆

Products

产品目录编号包装 数量 / 包装
5.30153.0001 玻璃瓶 25 mg
Description
OverviewA cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50 > 100 µM). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50 = 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530153
Brand Family Calbiochem®
SynonymsSTAT3 Signaling Inhibitor, FLLL32
References
ReferencesWu, J., et al. 2014. Oncogene 33,173.
Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
Li, L., et al. 2010. Cancer Res. 70, 2445.
Product Information
CAS number1260115-54-5
FormYellow powder
Hill FormulaC₂₈H₃₂O₆
Chemical formulaC₂₈H₃₂O₆
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetJAK2
Primary Target IC<sub>50</sub>5 µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
5.30153.0001 04055977241242

Documentation

JAK2 Inhibitor X, FLLL32 - 1260115-54-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

参考

参考信息概述
Wu, J., et al. 2014. Oncogene 33,173.
Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
Li, L., et al. 2010. Cancer Res. 70, 2445.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2014 JSW
SynonymsSTAT3 Signaling Inhibitor, FLLL32
DescriptionA cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50 > 100 µM). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50 = 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1260115-54-5
Chemical formulaC₂₈H₃₂O₆
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, J., et al. 2014. Oncogene 33,173.
Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
Li, L., et al. 2010. Cancer Res. 70, 2445.