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428201 LDN-211904 - CAS 1198408-78-4 - Calbiochem

LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

LDN-211904 - CAS 1198408-78-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: EphB3 inhibitor, LDN-211904, N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate

Primary Target: Erythropoietin-producing hepatocellular carcinoma (Eph)
428201
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1198408-78-4C₂₁H₂₁ClN₄O₅

Products

产品目录编号包装 数量 / 包装
428201-5MGCN 玻璃瓶 5 mg
Description
OverviewA pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 µM in cells. When profiled against a panel of 288 kinases at 5 µM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik.
Catalogue Number428201
Brand Family Calbiochem®
SynonymsEphB3 inhibitor, LDN-211904, N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate
References
ReferencesQiao, L., et al. 2011, Bioorg. Med. Chem. Lett. 19, 6122
Product Information
CAS number1198408-78-4
FormOff-white solid
Hill FormulaC₂₁H₂₁ClN₄O₅
Chemical formulaC₂₁H₂₁ClN₄O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetErythropoietin-producing hepatocellular carcinoma (Eph)
Primary Target IC<sub>50</sub>79 nM
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
428201-5MGCN 04055977210064

Documentation

LDN-211904 - CAS 1198408-78-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

LDN-211904 - CAS 1198408-78-4 - Calbiochem 分析证书

标题批号
428201

参考

参考信息概述
Qiao, L., et al. 2011, Bioorg. Med. Chem. Lett. 19, 6122
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-July-2012 JSW
SynonymsEphB3 inhibitor, LDN-211904, N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate
DescriptionA pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 µM in cells. When profiled against a panel of 288 kinases at 5 µM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik.
FormOff-white solid
CAS number1198408-78-4
Chemical formulaC₂₁H₂₁ClN₄O₅
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml; clear, nearly colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesQiao, L., et al. 2011, Bioorg. Med. Chem. Lett. 19, 6122