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14-728 Mer Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882, for use in Kinase Assays.

Mer Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-728
10 µg  
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number14-728
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMer Protein, active, 10 µg
OverviewN-terminal GST-tagged, recombinant, human Mer, amino acids 557-882
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Gene Symbol
  • MERTK
  • MGC133349
  • c-mer
  • mer
  • MER
  • MER-PEN
Protein TargetMer
Purification MethodGlutathione-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummarySIZE: 999 amino acids; 110249 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
DISEASE: SwissProt: Q12866 # Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
SIMILARITY: SwissProt: Q12866 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight64.4kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDI
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
14-728 04053252673702

相关产品和应用

Alternative Packsize

产品目录编号 描述
14-728M Mer Protein, active, 250 µg

产品族

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种类

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases