Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

481408 NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine

Primary Target: Blocks nuclear translocation of NF-κB p65 and its transcription activity
481408
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
749886-87-1C₁₆H₂₀N₂

Products

产品目录编号包装 数量 / 包装
481408-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Catalogue Number481408
Brand Family Calbiochem®
Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
References
ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
Product Information
CAS number749886-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₂₀N₂
Chemical formulaC₁₆H₂₀N₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
Biological Information
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
481408-5MGCN 07790788050672

Documentation

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem 分析证书

标题批号
481408

参考

参考信息概述
Shin, H.M., et al. 2004. FEBS Lett. 571, 50.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
DescriptionA cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number749886-87-1
Chemical formulaC₁₆H₂₀N₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.