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480060 Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem

The Necrosis Inhibitor, IM-54, also referenced under CAS 861891-50-1, selectively blocks oxidative stress-induced necrotic cell death. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 2-(1H-Indol-3-yl)-3-pentylamino-maleimide

Primary Target: Blocks oxidative stress-induced necrotic cell death
480060
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
861891-50-1C₁₉H₂₃N₃O₂

Products

产品目录编号包装 数量 / 包装
480060-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
Catalogue Number480060
Brand Family Calbiochem®
Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
References
ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
Product Information
CAS number861891-50-1
ATP CompetitiveN
FormYellow orange solid
Hill FormulaC₁₉H₂₃N₃O₂
Chemical formulaC₁₉H₂₃N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBlocks oxidative stress-induced necrotic cell death
Primary Target IC<sub>50</sub>(~3 µM prevented ~50% cell death in HL60 cells exposed to 100 µM H₂O₂).
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
480060-5MGCN 04055977201864

Documentation

Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem 分析证书

标题批号
480060

参考

参考信息概述
Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
DescriptionA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
FormYellow orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number861891-50-1
Chemical formulaC₁₉H₂₃N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.