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528150 PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem

PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PARP
528150
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
344458-15-7C₁₇H₁₇N₃O₂ · HCl

Products

产品目录编号包装 数量 / 包装
528150-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
528150-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
Catalogue Number528150
Brand Family Calbiochem®
References
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
Product Information
CAS number344458-15-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₇N₃O₂ · HCl
Chemical formulaC₁₇H₁₇N₃O₂ · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).
Biological Information
Primary TargetPARP
Primary Target IC<sub>50</sub>EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
528150-1MGCN 04055977196405
528150-5MGCN 04055977196412

Documentation

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem 分析证书

标题批号
528150

参考

参考信息概述
Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-January-2008 JSW
DescriptionA water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number344458-15-7
Chemical formulaC₁₇H₁₇N₃O₂ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.