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528118 PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

PI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X

528118
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
371242-69-2C₂₂H₁₉N₇O

Products

产品目录编号包装 数量 / 包装
528118-5MGCN 5 mg
Description
OverviewA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
Catalogue Number528118
Brand Family Calbiochem®
SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
References
ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
Ali, K., et al. 2008. J. Immunol. 180, 2538.
Product Information
CAS number371242-69-2
FormWhite powder
Hill FormulaC₂₂H₁₉N₇O
Chemical formulaC₂₂H₁₉N₇O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
528118-5MGCN 04055977197013

Documentation

PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem 分析证书

标题批号
528118

参考

参考信息概述
Billottet, C., et al. 2009. Cancer Res. 69,1027.
Ali, K., et al. 2008. J. Immunol. 180, 2538.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-September-2010 RFH
SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
DescriptionA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
FormWhite powder
CAS number371242-69-2
Chemical formulaC₂₂H₁₉N₇O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
Ali, K., et al. 2008. J. Immunol. 180, 2538.