559303 Sigma-AldrichSANT-1 - CAS 304909-07-7 - Calbiochem
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
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同义词: Shh Signaling Antagonist V
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 304909-07-7 | C₂₃H₂₇N₅ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 559303-5MGCN | 塑胶安瓿;塑胶针药瓶 | 5 mg |
| Description | |
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| Overview | A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay). |
| Catalogue Number | 559303 |
| Brand Family | Calbiochem® |
| Synonyms | Shh Signaling Antagonist V |
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| References | Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
| Product Information | |
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| CAS number | 304909-07-7 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₃H₂₇N₅ |
| Chemical formula | C₂₃H₂₇N₅ |
| Reversible | N |
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| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 559303-5MGCN | 04055977192414 |
Documentation
SANT-1 - CAS 304909-07-7 - Calbiochem MSDS
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SANT-1 - CAS 304909-07-7 - Calbiochem 分析证书
| 标题 | 批号 |
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| 559303 |
参考
| 参考信息概述 |
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| Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |