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573126 STAT3 Inhibitor XI, STX-0119 - CAS 851095-32-4 - Calbiochem

The STAT3 Inhibitor XI, STX-0119 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide

573126
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
851095-32-4C₂₂H₁₄N₄O₃

Products

产品目录编号包装 数量 / 包装
573126-25MGCN 玻璃瓶 25 mg
Description
OverviewA cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100 µM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
Catalogue Number573126
Brand Family Calbiochem®
SynonymsN-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
References
ReferencesAshizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.
Product Information
CAS number851095-32-4
FormGreyish to off-white solid
Hill FormulaC₂₂H₁₄N₄O₃
Chemical formulaC₂₂H₁₄N₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
573126-25MGCN 04055977266078

Documentation

STAT3 Inhibitor XI, STX-0119 - CAS 851095-32-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

STAT3 Inhibitor XI, STX-0119 - CAS 851095-32-4 - Calbiochem 分析证书

标题批号
573126

参考

参考信息概述
Ashizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.

技术信息

标题
JAK/STAT Signaling Research Focus
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-October-2012 JSW
SynonymsN-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
DescriptionA cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity in nuclear extract from IL-6-stimulated MDA-MB-468 cells (by 74% at 50 µM) and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 50% and 99%, respectively, at 74 and 100 µM), as well as inhibit the expression of STAT3 target genes, c-myc, cyclin D1, and survivin, both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
FormGreyish to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number851095-32-4
Chemical formulaC₂₂H₁₄N₄O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Standard Handling
ReferencesAshizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.