566224 Sigma-AldrichSialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase.
More>> Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug
Recommended Products
概述
| Replacement Information |
|---|
重要规格表
| Empirical Formula |
|---|
| C₂₂H₃₀FNO₁₄ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 566224-10MGCN | 玻璃瓶 | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable sialylic acid analog that upon cellular uptake is transformed into a CMP-Neu5Ac (Cat. No. 233264) mimetic bearing a C3 fluorine substituent at the axial position, effectively inhibiting sialyltransferase in a donor substrate CMP-Neu5Ac-competitive manner. Shown to effectively abloishes HL-60 cell surface SLeX expression (by >95%; 200 µM for 5 days), resulting in dramatic reductions in cell surface E-selectin and P-selectin binding (by >95% and >80%, respectively), without affecting cell viability or proliferation. |
| Catalogue Number | 566224 |
| Brand Family | Calbiochem® |
| Synonyms | (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug |
| References | |
|---|---|
| References | Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661. |
| Product Information | |
|---|---|
| Form | White solid |
| Hill Formula | C₂₂H₃₀FNO₁₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. |
| Biological Information | |
|---|---|
| Primary Target | Sialyltransferase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 566224-10MGCN | 04055977191332 |
Documentation
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem MSDS
| 职位 |
|---|
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem 分析证书
| 标题 | 批号 |
|---|---|
| 566224 |
参考
| 参考信息概述 |
|---|
| Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661. |